Leeds made one change from the win over Huddersfield with Billy Sharp coming into the starting eleven for Alex Mowatt. That approach gave Leeds more of a presence up front but it also left them exposed at several stages of the encounter.
With Brentford possessing plenty of dangerous players, the opening exchanges were expected to be cautious from Leeds but they started with confidence. Striker Steve Morison saw his header find the target but it was saved by David Button after a good cross from Charlie Taylor.
Captain Liam Cooper could have fired Leeds in front but his near-post flick was unable to find the net, Sol Bamba also missed the ball at the far post.
Marco Silvestri was the saviour on two occasions in the first half as Brentford charged forward. Andre Gray was left unmarked but the Italian saved his effort, before stopping Jota's close range strike.
Leeds continued to try and create opportunities but were unable to really put any pressure on the Brentford goal during the first 45 minutes.
The Whites were constantly being frustrated by the refereeing decisions, with Rodolph Austin being brought down in the box via a blatant push. Other claims could have been described as 50/50 but Neil Redfearn was pulling his hair out on the sideline.
Another dubious call from the ref was summed up seconds later when the Bees took the lead. A possible handball was ignored and Alex Pritchard tapped the ball in at the far post. Leeds could have done more with chances falling to Morison and Austin but Billy Sharp was inches wide from pulling the game level.
Mirco Antenucci and Edgar Cani were thrown on towards the end and the big man nearly scored on his debut. A goalmouth scramble saw Sharp miss and the rebound was blocked by three Brentford defenders.
In the end Leeds were below their best with the formation not helping but on another day they could have had a number of calls in their favour. Next up is Reading on Tuesday, let's hope the 4-3-2-1 returns.