Neil Redfearn's side showed their class as they repeated a similar performance to that shown in the win over Huddersfield earlier this season.
Jason Pearce returned to the starting line-up after serving a one-match suspension for picking up two yellow cards. He replaced Giuseppe Belluschi who was suspended but United's defence had nothing to do for the first 45 minutes.
Leeds started the game at a frantic pace and had chances through Souleymane Doukara and Mirco Antenucci. Adryan was also finding space on the edge of the box as Blackpool looked stunned early on.
The right-hand side of Leeds' attack was a constant threat, with Sam Byram returning to his best form as he linked up well with Lewis Cook and Alex Mowatt.
United went in front through Liam Cooper as the calm centre-back thumped the ball into the net after a corner.
Redfearn's men doubled their advantage thanks to a brilliant mazy run from Adryan. The Brazilian picked up the ball on the edge of his box before running the full length of the field and teeing up Doukara who rolled the ball home.
Antenucci then got the perfect chance to celebrate the birth of his daughter as he saw his shot deflected before going into the net on the stroke of half-time.
The second-half was a different story, with Blackpool looking a lot tighter in the middle. Leeds didn't have the same zest about their play and the crowd showed their frustration and some were worried when substitute Nile Ranger scored a consolation goal.
In the end Leeds' incredible performance in the first half was enough and Redfearn now has the perfect opportunity to work with his squad during the international break.